Genomics Core Facilities in Seychelles
Engineering Excellence & Technical Support
Genomics Core Facilities solutions for Research & Discovery (R&D). High-standard technical execution following OEM protocols and local regulatory frameworks.
Next-Generation Sequencing (NGS) Powerhouse
Leveraging state-of-the-art Illumina NovaSeq X Plus and Nanopore PromethION platforms, our core facility delivers high-throughput, cost-effective genomic sequencing for diverse research needs. From whole-genome sequencing of endemic species to targeted exome sequencing for disease studies, we provide unparalleled data quality and rapid turnaround times, driving critical discoveries in Seychelles' unique biodiversity and public health landscape.
Advanced Bioinformatics & Data Analytics Suite
Our robust bioinformatics infrastructure, powered by high-performance computing clusters and curated databases, ensures efficient processing, analysis, and interpretation of complex genomic data. We offer expert support in variant calling, functional annotation, comparative genomics, and population structure analysis, empowering researchers to extract meaningful insights from their sequencing projects and contribute to informed conservation and health strategies for the Seychelles.
Comprehensive Genomic Sample Management & Expertise
From meticulous sample collection and preservation protocols for environmental and clinical specimens to advanced DNA/RNA extraction techniques (including specialized methods for challenging matrices), our core facility ensures the highest quality starting material for all genomic applications. Our experienced team provides tailored guidance and hands-on training, fostering genomic research capacity and accelerating groundbreaking projects within the Seychelles.
What Is Genomics Core Facilities In Seychelles?
Genomics Core Facilities represent specialized centers providing access to advanced technologies and expertise for the high-throughput analysis of genetic material (DNA and RNA). In the context of Seychelles, such a facility would offer state-of-the-art instrumentation, computational resources, and skilled personnel to support a broad spectrum of research, diagnostic, and industrial applications. This service enables comprehensive exploration of an organism's genome, transcriptome, epigenome, and proteome, facilitating discoveries and advancements in various scientific and applied fields. The scope of services typically encompasses sample preparation, library construction, sequencing (e.g., whole-genome, exome, RNA-seq), genotyping, epigenomic profiling (e.g., methylation analysis), and bioinformatics support for data analysis and interpretation. The establishment of a Genomics Core Facility in Seychelles would significantly enhance its capacity in areas such as biodiversity research, conservation genomics, public health initiatives, and potentially the development of biotechnological applications.
| Who Needs Genomics Core Facilities? | Typical Use Cases |
|---|---|
| Researchers (Academic & Government): Institutions involved in biological, medical, environmental, and agricultural sciences. | Biodiversity and Conservation Genomics: Characterizing endemic species, population genetics, phylogenomics, and environmental DNA (eDNA) analysis for biodiversity monitoring. Public Health and Medical Research: Pathogen surveillance and outbreak investigation (e.g., identifying novel viruses or antibiotic resistance genes), genetic predisposition studies, and population health assessments. Agricultural and Fisheries Research: Understanding genetic diversity in crops and livestock, improving breeding programs, and disease resistance studies. |
| Healthcare Providers & Diagnostic Laboratories: Hospitals, public health laboratories, and clinical research units. | Infectious Disease Diagnostics: Rapid identification and characterization of infectious agents, including novel strains and antimicrobial resistance. Genetic Screening and Diagnostics: Identifying genetic markers for inherited diseases or predispositions (though may be limited in scope initially depending on infrastructure). |
| Conservation Agencies & Environmental Organizations: Government ministries, NGOs focused on biodiversity and ecosystem health. | Species Identification and Monitoring: Using genetic markers for accurate species identification and tracking populations. Ecological Studies: Understanding ecological interactions and the genetic basis of adaptation to environmental changes. |
| Potentially the Private Sector (Future Development): Biotechnology companies, agricultural enterprises, or specialized service providers. | Bioprospecting: Identifying novel genes or compounds from local flora and fauna for potential commercial applications. Aquaculture and Agriculture: Improving selective breeding and disease management in local industries. |
Key Aspects of Genomics Core Facilities in Seychelles:
- Technological Infrastructure: Provision of next-generation sequencing (NGS) platforms (e.g., Illumina, Oxford Nanopore), single-cell genomics instruments, qPCR machines, and associated laboratory equipment.
- Expert Personnel: Staffed by molecular biologists, bioinformaticians, and laboratory technicians with specialized training in genomics workflows and data analysis.
- Service Offerings: Comprehensive services from experimental design and sample handling to data generation, quality control, and initial bioinformatics analysis.
- Data Management & Analysis: Robust infrastructure for data storage, management, and computational tools for processing and interpreting large-scale genomic datasets.
- Collaborative Environment: Facilitation of interdisciplinary research and collaboration among academic institutions, government agencies, and potentially private sector entities.
- Training & Education: Opportunities for skill development and capacity building for researchers and students in genomics techniques and bioinformatics.
Who Needs Genomics Core Facilities In Seychelles?
Genomics core facilities play a vital role in advancing scientific research and innovation. In Seychelles, while the immediate demand might seem niche, identifying potential users and their specific needs is crucial for establishing and sustaining such a resource. These facilities offer specialized equipment, expertise, and services that are often beyond the capacity of individual research groups or departments. Their presence can unlock new avenues of research, improve diagnostic capabilities, and contribute to a more robust scientific ecosystem.
| Customer/Department | Primary Needs/Services | Potential Applications |
|---|---|---|
| University of Seychelles (or future academic institutions) | DNA/RNA sequencing (Sanger, NGS), Genotyping, Gene expression analysis, Bioinformatics support | Basic biological research, understanding endemic species, disease mechanism studies |
| Ministry of Environment, Energy, and Climate Change | Environmental DNA (eDNA) analysis, Metagenomics, Population genetics, Biodiversity monitoring | Tracking invasive species, assessing marine ecosystem health, monitoring protected areas, understanding climate change impacts on flora and fauna |
| Ministry of Health (Public Health Laboratory) | Pathogen sequencing (viral, bacterial), Genetic susceptibility testing, Pharmacogenomics (future) | Outbreak surveillance, identifying drug resistance, understanding disease prevalence and risk factors |
| Ministry of Agriculture, Climate Change and Energy | Crop/livestock genetic diversity analysis, Pest/disease diagnostics, Marker-assisted selection | Improving local crop yields, ensuring food security, managing agricultural pests and diseases |
| Ministry of Fisheries and the Blue Economy | Stock assessment genetics, Species identification, Marine organism health monitoring | Sustainable fisheries management, identifying illegal fishing activities, understanding fish population dynamics |
| Conservation NGOs (e.g., Island Conservation Society, Nature Seychelles) | Species identification, Population structure analysis, Conservation genetics, eDNA for biodiversity assessment | Protecting endangered species, managing wildlife populations, habitat restoration effectiveness |
| Emerging Biotechnology/Agri-tech Startups | Custom sequencing services, Proof-of-concept studies, Development of diagnostic kits | Developing novel solutions for local industries, innovation in agriculture and marine sectors |
Target Customers and Departments for a Genomics Core Facility in Seychelles:
- Academic Research Institutions
- Government Environmental Agencies
- Healthcare and Diagnostic Laboratories
- Agricultural and Fisheries Departments
- Conservation Organizations
- Biotechnology Startups (emerging)
Genomics Core Facilities Process In Seychelles
The Genomics Core Facilities in Seychelles, while emerging, are designed to provide researchers with essential genomic services. The typical workflow, from an initial inquiry to the final execution of genomic analyses, is structured to ensure efficient project management and high-quality data generation. This process is crucial for advancing scientific research in the archipelago, supporting areas like biodiversity conservation, public health, and agricultural development. The core facility acts as a central hub, offering expertise and state-of-the-art equipment that may not be readily available to individual research groups.
| Stage | Description | Key Activities | Outputs |
|---|---|---|---|
| Inquiry & Consultation | Initial contact and discussion of research needs. | Email/meeting, defining project goals, feasibility assessment. | Project scope definition, initial advice on methods. |
| Proposal & Planning | Formalizing project details and experimental design. | Writing proposal, defining methods, timeline, budget. | Approved project proposal, detailed experimental plan. |
| Sample Submission & QC | Receiving and verifying sample quality. | Sample collection/transport, DNA/RNA quantification, integrity assessment. | QC reports, validated samples for processing. |
| Library Preparation | Preparing samples for sequencing. | DNA/RNA extraction, adapter ligation, amplification. | Sequencing-ready DNA/RNA libraries. |
| Sequencing | Generating raw DNA/RNA reads. | Loading libraries onto sequencers, running sequencing runs. | Raw sequencing data (FASTQ files). |
| Raw Data Processing | Initial cleaning and quality assessment of raw data. | Base calling, quality filtering, adapter trimming. | Cleaned raw sequencing data. |
| Bioinformatic Analysis | Analyzing sequencing data to extract biological information. | Alignment, variant calling, gene expression quantification, etc. | Processed and analyzed genomic data (e.g., VCF files, gene counts). |
| Interpretation & Reporting | Making sense of the analyzed data and presenting findings. | Statistical analysis, biological interpretation, report writing. | Comprehensive project report, visualizations. |
| Archiving & Sharing | Storing and potentially distributing data. | Data backup, metadata documentation, sharing as per agreement. | Archived data, shared datasets (if applicable). |
| Project Closure | Finalizing the project and providing support. | Deliverables submission, follow-up discussions. | Completed project, researcher satisfaction. |
Genomics Core Facilities Workflow in Seychelles
- Initial Inquiry and Consultation: Researchers with a genomic question or project idea initiate contact with the Genomics Core Facility. This typically involves an email or direct meeting to discuss the project's objectives, scope, and potential applications of genomic technologies. The core facility staff will assess the feasibility of the project and provide guidance on experimental design, sample requirements, and appropriate genomic methodologies.
- Project Proposal and Planning: Following the initial consultation, a formal project proposal is often developed. This document outlines the research questions, specific aims, proposed methods, timeline, budget, and expected deliverables. A detailed experimental plan is created in collaboration with the researcher and core facility staff, ensuring all logistical and technical aspects are considered.
- Sample Submission and Quality Control: Once the project is approved, researchers submit their biological samples. Strict protocols are followed for sample collection, preservation, and transportation to maintain sample integrity. Upon arrival at the core facility, samples undergo rigorous quality control (QC) checks. This may include visual inspection, DNA/RNA quantification (e.g., using Qubit or Nanodrop), and assessment of DNA/RNA integrity (e.g., using a Bioanalyzer or TapeStation). Samples that do not meet QC standards may require re-collection or optimization.
- Library Preparation: Based on the experimental design and the type of genomic analysis required (e.g., whole-genome sequencing, exome sequencing, RNA sequencing, genotyping), specialized libraries are prepared from the prepared DNA or RNA. This involves a series of enzymatic reactions to add adapters and barcodes necessary for sequencing and to amplify the DNA fragments. The specific steps are highly dependent on the chosen sequencing platform and application.
- Sequencing: The prepared libraries are loaded onto high-throughput sequencing instruments (e.g., Illumina platforms). The sequencing process generates millions to billions of short DNA reads, capturing the genetic information from the samples. The choice of sequencing platform and read length depends on the project's requirements and budget.
- Data Generation and Raw Data Processing: The sequencing instruments produce raw sequencing data, typically in FASTQ format. This raw data undergoes initial processing, including base calling and quality assessment. Tools are used to filter out low-quality reads and adapter sequences, ensuring the integrity of the data for downstream analysis.
- Bioinformatic Analysis: This is a critical stage where the raw sequencing data is transformed into meaningful biological insights. It involves a pipeline of bioinformatic tools and algorithms for tasks such as: * Alignment: Mapping reads to a reference genome or transcriptome. * Variant Calling: Identifying genetic variations (SNPs, indels, etc.). * Gene Expression Quantification: Measuring the abundance of RNA transcripts. * De Novo Assembly: Reconstructing genomes without a reference. * Functional Annotation: Assigning biological functions to genes and variants. * Statistical Analysis: Identifying significant patterns and differences.
- Data Interpretation and Reporting: The results of the bioinformatic analysis are interpreted in the context of the original research question. This often involves close collaboration between the core facility bioinformaticians and the researcher. A comprehensive report is generated, including raw data, processed data, analysis results, visualizations (e.g., graphs, charts, heatmaps), and a discussion of the findings. This report serves as the foundation for the researcher's publication or further research.
- Data Archiving and Sharing: Depending on institutional policies and project requirements, genomic data may be archived for future use or shared with collaborators or public repositories. The core facility typically maintains data management protocols to ensure secure storage and accessibility.
- Project Closure and Follow-up: Once the final report is delivered and data is archived, the project is considered closed. The core facility may offer follow-up support for data interpretation or potential future project phases.
Genomics Core Facilities Cost In Seychelles
Genomics core facilities in Seychelles are a developing area, and as such, specific, widely published pricing structures are not readily available. The cost of utilizing such services is influenced by a multitude of factors, primarily driven by the specialized nature of the equipment, consumables, skilled personnel required, and the overall operational overhead. Currently, the primary drivers of cost are likely to be international sourcing of reagents and equipment, as well as the need for specialized expertise which may involve training or bringing in external consultants. For the purposes of discussion, we can outline the typical pricing factors and provide estimated ranges in Seychellois Rupees (SCR), acknowledging these are speculative and subject to significant variation.
Key Pricing Factors:
- Type of Sequencing/Analysis: The complexity and depth of genomic analysis significantly impact cost. Whole genome sequencing, exome sequencing, targeted sequencing panels, RNA sequencing, and epigenetic analysis all have different reagent and processing costs.
- Sample Type and Preparation: The source of the DNA/RNA (e.g., blood, tissue, saliva, environmental samples) and the required level of sample preparation (e.g., DNA extraction, library preparation methods) contribute to the overall expense.
- Throughput and Scale: The volume of samples processed will influence per-sample cost due to economies of scale. Larger projects may negotiate lower per-unit prices.
- Technology Platform: Different sequencing platforms (e.g., Illumina, Nanopore) have varying equipment, reagent, and operational costs.
- Bioinformatics Analysis: Data processing, alignment, variant calling, and downstream biological interpretation require significant computational resources and specialized bioinformatician time, adding to the cost.
- Personnel and Expertise: The cost of skilled technicians and bioinformaticians, as well as any external consultation required, is a major factor.
- Consumables and Reagents: The cost of enzymes, sequencing kits, buffers, and other laboratory consumables, often imported, is a significant expense.
- Equipment Maintenance and Depreciation: The capital investment and ongoing maintenance of high-throughput sequencing machines and associated equipment contribute to overhead.
- Facility Overhead: This includes laboratory space rental, utilities, administrative support, and quality control measures.
- Intellectual Property and Data Security: Ensuring secure storage and handling of sensitive genomic data can incur additional costs.
Estimated Cost Ranges in Seychellois Rupees (SCR):
Given the nascent stage of dedicated genomics core facilities in Seychelles, it's important to note that these are hypothetical ranges. Costs are likely to be higher than in countries with established infrastructure. These estimates are based on global trends adjusted for potential import costs and the current economic landscape in Seychelles.
| Service/Analysis Type | Estimated Cost Range (SCR) | Notes |
|---|---|---|
| DNA Extraction (per sample) | 1,500 - 3,000 | Basic extraction kit and manual processing. |
| Library Preparation (per sample) | 4,000 - 8,000 | Standard Illumina library preparation. |
| Targeted Sequencing Panel (e.g., 500 genes) | 20,000 - 50,000 per sample | Includes library prep and sequencing, basic analysis. |
| Whole Exome Sequencing (WES) | 50,000 - 120,000 per sample | Includes library prep, sequencing, alignment, variant calling. |
| Whole Genome Sequencing (WGS) | 150,000 - 400,000+ per sample | Includes library prep, sequencing, comprehensive analysis. |
| RNA Sequencing (RNA-Seq) (per sample) | 40,000 - 100,000 | Includes library prep, sequencing, basic differential gene expression analysis. |
| Bioinformatics Analysis (hourly/project) | 1,000 - 3,000 per hour | Depending on complexity and bioinformatician expertise. Project-based quotes also common. |
Factors Influencing Genomics Core Facility Costs in Seychelles
- Type of Sequencing/Analysis (e.g., WGS, Exome, RNA-Seq)
- Sample Type and Preparation Methods
- Project Scale and Throughput
- Sequencing Technology Platform Utilized
- Complexity of Bioinformatics and Data Analysis
- Availability of Skilled Personnel
- Cost of Imported Reagents and Consumables
- Equipment Purchase, Maintenance, and Depreciation
- General Facility Operational Overhead
- Data Storage and Security Requirements
Affordable Genomics Core Facilities Options
Establishing and maintaining a genomics core facility can be a significant investment, but various strategies and options exist to make advanced genomic services more accessible and affordable. This document outlines affordable genomics core facility options, focusing on value bundles and cost-saving strategies.
| Value Bundle Type | Description | Cost-Saving Benefit | Typical Components |
|---|---|---|---|
| Standard Sequencing Package | Pre-defined kits and services for common sequencing applications. | Bulk purchasing discounts on reagents, streamlined workflows, predictable pricing. | Library preparation, sequencing run (e.g., Illumina NovaSeq, MiSeq), basic data QC. |
| Targeted Resequencing Bundle | Focuses on specific genes or regions of interest, often using amplicon sequencing or probe-based enrichment. | Reduced sequencing depth and data analysis complexity compared to whole-genome sequencing. | Primer design, amplicon library preparation, sequencing, variant calling for targeted regions. |
| RNA-Seq Analysis Bundle | Combines library preparation, sequencing, and a defined level of bioinformatics analysis for gene expression studies. | Economies of scale for library prep and sequencing; predictable bioinformatics costs. | RNA extraction (optional), library preparation, sequencing, alignment, gene expression quantification, differential expression analysis. |
| Single-Cell Genomics Bundle | Services for analyzing individual cells, such as single-cell RNA-seq (scRNA-seq). | Specialized protocols and platforms designed for high throughput, leveraging vendor expertise. | Cell isolation, library preparation, sequencing, basic UMI counting and clustering. |
| Custom Project Design & Consultation | Includes upfront consultation to design optimal experiments and tailored service packages. | Reduces wasted experiments and resources by ensuring experimental design is efficient and appropriate. | Experimental design consultation, custom library preparation, sequencing, and bioinformatics support. |
| Multi-Omics Integration Bundle | Combines data from different omics layers (e.g., genomics, transcriptomics, epigenomics) with integrated analysis. | Streamlined data processing and analysis pipelines; potential for bulk discounts on individual omics services. | Multiple library preparations, sequencing, and advanced bioinformatics for data integration. |
Key Strategies for Affordable Genomics Cores
- {"title":"Shared Resources & Collaborative Models","description":"Institutions can pool resources and expertise to establish shared core facilities, reducing individual costs. This can involve inter-departmental collaboration within a single institution or partnerships between multiple universities, research institutes, or even with industry."}
- {"title":"Outsourcing & Service Providers","description":"Leveraging commercial genomics service providers can be more cost-effective than building and staffing an in-house core, especially for specialized or low-volume services. These providers often benefit from economies of scale."}
- {"title":"Technology Optimization & Standardization","description":"Focusing on high-throughput, automated platforms and standardizing workflows can reduce per-sample costs. This often involves investing in efficient instrumentation and optimizing protocols for scale."}
- {"title":"Grant Funding & External Support","description":"Actively seeking grant opportunities (e.g., NIH, NSF, foundations) can provide crucial funding for equipment, personnel, and operational expenses, making services more affordable for users."}
- {"title":"Training & Skill Development","description":"Investing in comprehensive training for core facility staff and users can improve efficiency, reduce errors, and enable the adoption of cost-effective technologies. Empowering researchers to perform some tasks themselves (with guidance) can also lower overall costs."}
- {"title":"Tiered Service Models","description":"Offering different service levels (e.g., basic sequencing vs. advanced bioinformatics analysis) can cater to a wider range of budgets and needs."}
Verified Providers In Seychelles
In the pristine beauty of Seychelles, access to reliable and high-quality healthcare is paramount. When seeking medical services, particularly those involving specialized treatments or elective procedures, identifying verified and reputable providers is crucial. Franance Health stands out as a beacon of trust and excellence within the Seychellois healthcare landscape. Their unwavering commitment to patient well-being, coupled with stringent credentialing processes, positions them as the definitive best choice for those prioritizing safety, efficacy, and a superior healthcare experience.
| Provider Category | Franance Health Verification Process | Key Benefits for Patients |
|---|---|---|
| Specialist Physicians (e.g., Cardiologists, Orthopedic Surgeons, Dermatologists) | Verification of medical degree, board certification, residency completion, peer reviews, and hospital affiliations. | Access to highly qualified specialists with international experience; accurate diagnosis and treatment plans. |
| Surgeons | Detailed review of surgical training, specialization, case logs, complication rates, and ongoing professional development. | Safe and effective surgical interventions performed by experienced surgeons; reduced risk of complications. |
| Diagnostic Imaging Centers (e.g., MRI, CT Scan, Ultrasound) | Accreditation of facilities by recognized bodies, qualification of radiographers and technicians, and quality assurance protocols. | Reliable and accurate diagnostic imaging; timely results for effective treatment planning. |
| Rehabilitation and Physiotherapy Centers | Certification of therapists, verification of therapeutic modalities offered, and adherence to evidence-based rehabilitation practices. | Personalized rehabilitation programs for faster recovery; improved mobility and quality of life. |
| Dental Professionals | Verification of dental degrees, specialist certifications, and adherence to stringent sterilization and safety protocols. | Comprehensive dental care from qualified dentists; prevention and treatment of oral health issues. |
Why Franance Health is Your Best Choice in Seychelles:
- Uncompromising Quality Standards: Franance Health adheres to the highest international standards for healthcare delivery, ensuring that every provider within their network meets rigorous benchmarks for clinical expertise, patient care, and ethical practice.
- Rigorous Credentialing: We meticulously vet all our affiliated healthcare professionals. This process includes verifying medical licenses, educational qualifications, board certifications, and a proven track record of successful patient outcomes. This ensures you are in the hands of truly qualified experts.
- Patient-Centric Approach: At Franance Health, the patient's needs and comfort are at the forefront. Our network prioritizes clear communication, empathetic care, and personalized treatment plans tailored to individual requirements.
- Access to Specialized Expertise: Whether you require advanced surgical procedures, specialized diagnostics, or niche medical consultations, Franance Health connects you with a diverse range of highly skilled specialists, many of whom have international experience and training.
- State-of-the-Art Facilities and Technology: We partner with facilities equipped with modern medical technology and infrastructure, facilitating accurate diagnoses and effective treatments, ultimately leading to better patient outcomes.
- Transparent and Trustworthy: Franance Health is dedicated to fostering an environment of trust. We believe in transparency regarding provider credentials, treatment options, and associated costs, empowering you to make informed decisions about your health.
- Seamless Healthcare Journey: From initial consultation to post-treatment follow-up, Franance Health aims to provide a seamless and stress-free healthcare experience, minimizing administrative burdens and allowing you to focus on your recovery.
Scope Of Work For Genomics Core Facilities
This Scope of Work (SOW) outlines the technical deliverables and standard specifications for the Genomics Core Facilities. It details the services, methodologies, and quality control measures to be implemented. The goal is to provide high-quality genomic data and support to researchers, ensuring reproducibility and adherence to best practices.
| Service Category | Deliverable | Standard Specifications/Notes |
|---|---|---|
| Sample Preparation | Extracted DNA/RNA | Concentration: ≥ 50 ng/µL for DNA, ≥ 20 ng/µL for RNA. Purity: A260/A280 ratio 1.8-2.0, A260/A230 ratio ≥ 1.8. Integrity: RNA Integrity Number (RIN) ≥ 7 for most RNA-Seq applications. QC performed by Qubit and Bioanalyzer/TapeStation. |
| Library Preparation | Sequencing-ready libraries | Library yield: Target range based on application (e.g., 200-600 bp insert size for Illumina short-read). QC by Bioanalyzer/TapeStation and Qubit. Adapter ligation efficiency monitored. |
| NGS Sequencing | Raw sequencing data (FASTQ format) | Sequencing depth and coverage will be application-dependent and agreed upon during project design. Quality score threshold: Phred Q30 ≥ 85% for Illumina. Read length and format as per platform. |
| Long-Read Sequencing | Raw sequencing data (e.g., .fastq, .bam) | Data quality metrics (e.g., read length N50, average read quality) will be reported. Application-specific coverage targets apply. |
| Single-Cell Genomics | Processed single-cell data (e.g., count matrices, UMAP coordinates) | Cell barcode and UMI filtering, alignment to reference genome, generation of gene expression matrices. QC metrics include number of cells captured, genes per cell, and mitochondrial content. |
| Bioinformatics Analysis | Variant calling, gene expression analysis, pathway enrichment, differential expression reports | Standard pipelines for each application. Customized analysis available upon request. Data formats: VCF, BAM, BED, tables, figures. All analyses will be documented with versioning of tools and parameters. |
| Quality Assurance | QC reports for each stage | Regular calibration of equipment. Use of positive and negative controls. Data integrity checks throughout the workflow. Adherence to established SOPs. |
| Data Management | Secure data storage and transfer | Raw and processed data will be stored securely for a defined period (e.g., 1 year). Data transfer via secure protocols (e.g., SFTP, Globus). |
Key Genomics Services
- DNA/RNA Extraction and Quality Control
- Library Preparation for various sequencing platforms (e.g., Illumina, PacBio, Nanopore)
- Next-Generation Sequencing (NGS) services (e.g., Whole Genome Sequencing, Whole Exome Sequencing, RNA-Seq, ChIP-Seq, ATAC-Seq)
- Long-Read Sequencing services
- Single-Cell Genomics (e.g., scRNA-Seq, scATAC-Seq)
- Genotyping and SNP arrays
- Bioinformatics analysis and data interpretation
- Consultation and experimental design support
Service Level Agreement For Genomics Core Facilities
This Service Level Agreement (SLA) outlines the guaranteed response times and uptime for services provided by the Genomics Core Facilities. It aims to ensure reliable and efficient access to our cutting-edge genomic technologies and expert support.
| Service Category | Response Time (Business Hours) | Uptime Guarantee |
|---|---|---|
| Technical Support & Consultation | 4 Business Hours | 98% Uptime (excluding scheduled maintenance) |
| Sample Drop-off & Intake | 2 Business Hours | 99% Uptime (facility operational hours) |
| NGS Library Preparation (Standard Protocols) | 3 Business Days (upon receipt of samples) | 97% Uptime for core equipment |
| NGS Sequencing (Standard Run Times) | 7 Business Days (upon completion of library prep) | 97% Uptime for core equipment |
| Bioinformatics Data Delivery (Primary Analysis) | 5 Business Days (after sequencing completion) | 99% Uptime for bioinformatics servers |
| Emergency Support (Critical Equipment Failure) | 1 Business Hour | N/A (Focus on rapid resolution) |
Scope of Services Covered
- Next-Generation Sequencing (NGS) library preparation and sequencing.
- Single-cell RNA sequencing.
- Long-read sequencing.
- Genotyping and SNP analysis.
- Bioinformatics analysis support (data preprocessing, QC, primary analysis).
- Consultation on experimental design and protocol optimization.
Frequently Asked Questions
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