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Genomics Core Facilities in Mauritania Engineering Excellence & Technical Support

Genomics Core Facilities solutions for Research & Discovery (R&D). High-standard technical execution following OEM protocols and local regulatory frameworks.

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Next-Generation Sequencing (NGS) Hub

State-of-the-art NGS platforms enabling high-throughput whole genome, exome, and targeted sequencing for diverse research applications, from infectious disease surveillance to agricultural genomics.

Advanced Bioinformatics Pipeline

Robust computational infrastructure and expert bioinformaticians providing comprehensive data analysis, variant calling, genome assembly, and interpretation services to unlock insights from complex genomic data.

Sample Management & QC

Strict protocols for DNA/RNA extraction, library preparation, and quality control, ensuring high-quality, reliable genomic data for critical research and diagnostic projects.

What Is Genomics Core Facilities In Mauritania?

Genomics Core Facilities in Mauritania, though nascent, represent specialized centers providing advanced genomic technologies and expertise. These facilities are crucial for enabling high-throughput sequencing, genotyping, and other molecular biology applications that are fundamental to modern biological research, clinical diagnostics, and agricultural development. Their establishment and operation are driven by the increasing demand for sophisticated genomic data to address national priorities in public health, food security, and biodiversity conservation.

Who Needs Genomics Core Facilities?Typical Use Cases
Researchers (Academia & Government): Requiring genomic data for fundamental biological studies, disease mechanism investigations, and discovery research.Healthcare Providers & Public Health Institutions: For pathogen surveillance (e.g., infectious disease outbreaks), genetic disease diagnosis, pharmacogenomics, and cancer genomics.Agricultural Sector (Farmers, Researchers, Industry): For crop and livestock breeding (e.g., identifying desirable traits, improving disease resistance), animal health monitoring, and understanding agricultural biodiversity.Environmental Scientists & Conservationists: For biodiversity assessment, population genetics studies, monitoring ecosystem health, and identifying species.Students & Technicians: Seeking hands-on experience and training in advanced molecular biology techniques and bioinformatics.
Infectious Disease Surveillance: Rapid identification and tracking of novel or re-emerging pathogens (e.g., SARS-CoV-2, Ebola) to inform public health interventions.Rare Disease Diagnosis: Identifying genetic mutations responsible for inherited disorders in individuals and families.Personalized Medicine: Tailoring treatment strategies based on an individual's genetic makeup, particularly in oncology.Crop Improvement: Enhancing yield, nutritional value, and resilience to environmental stressors (drought, salinity) in staple crops.Livestock Breeding: Improving productivity, disease resistance, and reproductive efficiency in animal populations.Biodiversity Inventory: Cataloging and understanding the genetic diversity of flora and fauna for conservation planning.Metagenomics: Studying microbial communities in various environments (e.g., soil, water, human gut) to understand their functions and impacts.Forensic Science: DNA profiling for identification purposes (though may require specialized forensic labs).

Key Aspects of Genomics Core Facilities

  • Service Provision: Offer access to state-of-the-art instrumentation and trained personnel for DNA/RNA extraction, library preparation, various sequencing platforms (e.g., Illumina, Oxford Nanopore), genotyping technologies, and bioinformatic analysis.
  • Expertise and Training: Provide scientific consultation, experimental design support, data interpretation, and training workshops for researchers and technicians, fostering local capacity in genomics.
  • Infrastructure: Maintain controlled laboratory environments, specialized equipment, and secure data storage solutions necessary for reliable and reproducible genomic workflows.
  • Collaboration: Facilitate interdisciplinary research by connecting researchers from different institutions and sectors, fostering a collaborative ecosystem for genomic innovation.

Who Needs Genomics Core Facilities In Mauritania?

Genomics core facilities are essential for advancing research and diagnostic capabilities. In Mauritania, their impact can be particularly transformative for various sectors and institutions. Identifying the key stakeholders and their specific needs is crucial for the successful establishment and operation of such facilities. This document outlines the primary target customers and departments that would benefit from and contribute to a genomics core facility in Mauritania.

Department/SectorKey Needs & Applications of GenomicsExamples of Projects
University Research Departments (e.g., Biology, Medicine, Agriculture)Basic research, training, manuscript publication, grant applications. Applications include understanding local disease epidemiology, identifying genetic predispositions, plant and animal breeding, and biodiversity studies.Genotyping local livestock for desirable traits, sequencing pathogen genomes to track outbreaks, identifying genetic factors for common diseases in Mauritanian populations, studying the genetic diversity of native plant species.
Clinical Pathology & Diagnostic Laboratories (Public & Private Hospitals)Accurate and rapid diagnosis of infectious diseases, inherited disorders, and cancers. Personalized medicine approaches. Antimicrobial resistance profiling.Diagnostic sequencing for rare genetic diseases, molecular identification of infectious agents (bacteria, viruses, parasites), pharmacogenomic testing to optimize drug prescriptions, rapid identification of antibiotic resistance genes in pathogens.
Ministry of Health & Public Health InstitutesEpidemiological surveillance, outbreak investigation and response, disease burden estimation, development of national health policies, vaccine development support.Genomic surveillance of emerging infectious diseases (e.g., COVID-19, Dengue), identifying sources and transmission routes of outbreaks, tracking the evolution of local pathogens, monitoring the genetic diversity of disease vectors.
Ministry of Agriculture & LivestockImproving crop resilience to climate change and pests, enhancing livestock productivity, developing disease-resistant breeds, ensuring food security.Marker-assisted selection for drought-tolerant crops, genetic improvement of local cattle and sheep breeds, identifying genes responsible for disease resistance in poultry, assessing genetic diversity in native crops for conservation.
Ministry of Environment & Sustainable DevelopmentBiodiversity assessment and conservation, environmental monitoring, understanding ecosystem health, species identification and tracking.Metabarcoding of soil or water samples to assess microbial diversity, genetic identification of endangered species, tracking illegal wildlife trade through DNA analysis, assessing the impact of pollution on aquatic organisms.
Veterinary ServicesDiagnosing and managing animal diseases, improving animal health and welfare, preventing zoonotic disease transmission.Identifying and characterizing animal pathogens, developing rapid diagnostic tests for livestock diseases, tracing the origin of animal disease outbreaks, genomic surveillance of zoonotic diseases.
Emerging Biotechnology Companies & Start-upsContract research services, product development (e.g., diagnostic kits, biopesticides), innovation in agricultural or health sectors.Custom DNA/RNA sequencing services, development of molecular markers for agricultural applications, gene editing services for research purposes, microbial strain characterization for industrial applications.

Target Customers & Departments for Genomics Core Facilities in Mauritania

  • {"title":"Academic & Research Institutions","description":"Universities and research centers form the bedrock of scientific inquiry. Genomics capabilities will empower their faculty and students to conduct cutting-edge research."}
  • {"title":"Healthcare & Clinical Laboratories","description":"Hospitals and diagnostic centers are crucial for patient care. Genomics can revolutionize disease diagnosis, prognosis, and personalized treatment."}
  • {"title":"Agricultural Sector","description":"Improving crop yields, livestock health, and disease resistance is vital for food security and economic development."}
  • {"title":"Environmental Agencies & Conservation Efforts","description":"Understanding biodiversity, tracking environmental changes, and managing natural resources will be enhanced by genomic insights."}
  • {"title":"Government Ministries & Public Health Agencies","description":"These bodies are responsible for national health strategies, disease surveillance, and policy development, all of which can be informed by genomics."}
  • {"title":"Biotechnology & Pharmaceutical Companies (Emerging)","description":"While currently nascent, a local genomics facility can foster the growth of these industries through contract research and development."}

Genomics Core Facilities Process In Mauritania

Genomics core facilities in Mauritania, while potentially nascent or in development, would likely follow a standardized workflow to ensure efficient and reliable sample processing. This workflow typically begins with an initial inquiry from a researcher or collaborator, followed by sample submission, quality control, library preparation, sequencing, data analysis, and finally, data delivery. Each stage involves specific steps, quality checks, and communication protocols to manage the genomic research process effectively. The exact implementation may vary based on the specific technologies available, the expertise of the staff, and the types of research being conducted.

StageDescriptionKey ActivitiesDeliverables/OutcomesPotential Challenges in Mauritania
Inquiry and ConsultationInitial contact from researcher to the core facility to discuss project needs.Understanding research goals, sample types, experimental design, and budget. Providing quotes and timelines. Advising on feasibility and best practices.Project proposal, cost estimate, preliminary experimental design recommendations.Limited awareness of genomics capabilities, difficulty in communication due to infrastructure or language barriers, lack of standardized research protocols among potential users.
Sample Submission and RegistrationFormal submission of biological samples for processing.Completing submission forms, packaging and shipping samples according to guidelines, barcode labeling and tracking of each sample.Registered samples with unique identifiers, sample metadata database.Lack of cold chain infrastructure for sample transport, inconsistent sample quality upon arrival, delays in sample receipt due to logistical issues.
Sample Quality Control (QC)Assessing the quality and quantity of extracted nucleic acids.Spectrophotometry (e.g., NanoDrop) for concentration and purity, Fluorometry (e.g., Qubit) for precise quantification, Gel electrophoresis or bioanalyzer for integrity and size distribution.Pass/fail report on sample suitability for library preparation.Limited access to advanced QC equipment, lack of trained personnel for troubleshooting, potential degradation of samples during transit.
Library PreparationConverting extracted nucleic acids into a format suitable for sequencing.DNA/RNA fragmentation, adapter ligation, amplification (PCR), cleanup steps. Specific protocols depend on the sequencing platform and application (e.g., whole genome, exome, RNA-Seq).Sequencing-ready libraries.Cost of reagents and specialized kits, availability of trained technicians for intricate lab work, maintaining sterile and controlled laboratory environments.
SequencingGenerating raw sequence data from the prepared libraries.Loading libraries onto the sequencing instrument, performing the sequencing run, initial data generation.Raw sequencing data (e.g., FASTQ files).High cost of sequencing instruments and maintenance, dependence on imported consumables, lack of readily available technical support for instrumentation.
Data Quality Control (QC)Assessing the quality of the generated raw sequencing data.Per-base quality scores (e.g., using FastQC), adapter contamination checks, sequence duplication assessment, GC content analysis.QC reports on raw data, identification of potential issues for downstream analysis.Need for specialized bioinformatics software and expertise, potential for data transfer issues from sequencers.
Data AnalysisProcessing and interpreting the sequencing data to extract biological insights.Alignment to a reference genome, variant calling, gene expression quantification, differential expression analysis, functional enrichment analysis, de novo assembly (if applicable).Analyzed data (e.g., variant calls, expression matrices), figures, tables, and preliminary biological interpretations.Scarcity of highly skilled bioinformaticians, limited access to high-performance computing (HPC) resources, lack of well-curated reference genomes for local species.
Data Delivery and ReportingProviding the analyzed data and reports to the researcher.Transferring data through secure means (e.g., external hard drives, cloud storage), providing detailed reports on methodology, results, and interpretation. Archiving data.Finalized data files, comprehensive project report, archived raw and processed data.Reliable and secure data storage solutions, ensuring data privacy and intellectual property rights, effective communication of complex results to researchers.

Genomics Core Facilities Workflow in Mauritania

  • Inquiry and Consultation
  • Sample Submission and Registration
  • Sample Quality Control (QC)
  • Library Preparation
  • Sequencing
  • Data Quality Control (QC)
  • Data Analysis
  • Data Delivery and Reporting

Genomics Core Facilities Cost In Mauritania

Genomics core facilities in Mauritania, like in many developing nations, face unique challenges in terms of infrastructure, skilled personnel, and the availability of advanced reagents and consumables. Consequently, the cost of genomics services can be highly variable and may not always align with international pricing structures. Factors influencing these costs include the specific technology employed (e.g., Sanger sequencing vs. next-generation sequencing), the scale of the project, the type of sample, the required turnaround time, and the operational overhead of the facility. Due to the nascent stage of advanced genomics infrastructure in Mauritania, many researchers might rely on international collaborations or send samples abroad for analysis, which introduces additional costs related to shipping, customs, and potentially higher service fees from overseas providers. Local facilities, if they exist and are adequately equipped, will likely price services competitively within the local economic context, balancing the need for sustainability with accessibility for researchers. The limited market size and potential reliance on government or grant funding can also shape pricing strategies. It's important to note that specific pricing information for genomics core facilities in Mauritania is not widely published, making it challenging to provide definitive ranges. However, we can discuss the influencing factors and potential cost drivers in the local currency, the Mauritanian Ouguiya (MRU).

Service Type (Illustrative Examples)Potential Pricing Factors (MRU)Estimated Range (MRU - Highly Approximate)
Sanger Sequencing (per reaction)Reagent costs, machine time, basic analysis.1,000 - 3,000 MRU
DNA Extraction (per sample)Kit costs, labor, sample processing.500 - 1,500 MRU
Library Preparation (per sample, basic NGS)Kit costs, specific library type, labor.5,000 - 15,000 MRU
Whole Genome Sequencing (per sample, low coverage)Sequencing run cost, reagents, library prep, data storage.50,000 - 150,000 MRU
Exome Sequencing (per sample)Capture kit costs, sequencing run, reagents, library prep.40,000 - 120,000 MRU
RNA Sequencing (per sample, basic analysis)Library prep, sequencing run, reagents, bioinformatics.60,000 - 200,000 MRU
Bioinformatics Analysis (per project/hours)Computational resources, expert time, analysis complexity.10,000 - 50,000 MRU (or as a percentage of sequencing cost)

Key Pricing Factors for Genomics Core Facilities in Mauritania:

  • Technology Employed (Sanger vs. NGS, specific NGS platforms)
  • Project Scale (number of samples, depth of sequencing)
  • Sample Type and Preparation Requirements (e.g., DNA extraction, library preparation complexity)
  • Turnaround Time (standard vs. rush services)
  • Reagent and Consumable Costs (often imported, subject to currency fluctuations and import duties)
  • Labor and Expertise (skilled technicians, bioinformaticians)
  • Infrastructure and Equipment Maintenance
  • Bioinformatics Analysis (data processing, variant calling, interpretation)
  • Shipping and Logistics (if samples are sent abroad)
  • Institutional Overhead and Profit Margins

Affordable Genomics Core Facilities Options

Genomics core facilities are crucial for cutting-edge research, but their costs can be prohibitive for many institutions. This document explores affordable options, focusing on the strategic use of value bundles and implementing effective cost-saving strategies. By understanding these approaches, researchers and institutions can leverage genomics technologies without breaking their budgets.

Strategy CategoryDescriptionPotential Cost SavingsConsiderations
Value BundlesPackages that combine sequencing, library preparation, and sometimes basic data analysis at a reduced per-unit cost compared to individual services.10-25% reduction on bundled services.Ensure the bundle meets project needs; avoid paying for unused services.
Bulk Purchasing/DiscountsNegotiating lower prices for reagents, consumables, or service volume commitments.Variable, can be significant for high-volume users.Requires accurate forecasting of needs; potential for waste if over-committed.
Standardization of ProtocolsAdopting standardized library preparation and sequencing methods across multiple projects and users.Reduced reagent waste, increased efficiency, potential for bulk purchasing of standardized kits.May limit flexibility for highly specialized applications.
Tiered Service OptionsOffering different service levels (e.g., standard vs. premium data analysis, rapid vs. standard turnaround) with corresponding price points.Allows users to select the most appropriate and affordable option for their project.Requires clear communication of service levels and their implications.
Collaborative Core FacilitiesSharing resources, equipment, and expertise between departments or institutions.Shared capital costs, reduced operational overhead per user.Requires strong governance, clear cost-sharing models, and effective communication.
Cloud-Based Data AnalysisLeveraging scalable cloud platforms (e.g., AWS, Google Cloud, Azure) for computational analysis.Pay-as-you-go model reduces upfront infrastructure investment; scales with project needs.Requires expertise in cloud computing; data security and transfer protocols are crucial.
Open-Source Software AdoptionUtilizing free and open-source bioinformatics tools instead of proprietary software licenses.Eliminates software licensing costs.Requires skilled bioinformaticians to implement and maintain; community support varies.

Key Concepts and Strategies

  • Value Bundles: Combining multiple services or consumables into a single package often at a discounted rate.
  • Cost-Saving Strategies: Techniques and approaches designed to reduce overall spending on genomics services.
  • Cloud Computing for Data Analysis: Utilizing scalable and cost-effective cloud platforms instead of on-premises infrastructure.
  • Collaborative Purchasing: Pooling resources with other institutions or research groups to negotiate better prices.
  • Reagent Optimization: Using smaller reaction volumes or alternative, less expensive reagents where appropriate.
  • Prioritization of Projects: Focusing resources on the most impactful research questions to avoid unnecessary sequencing.
  • Internal vs. External Core Facilities: Evaluating the cost-effectiveness of using an in-house facility versus a commercial service.
  • Service Tiering: Offering different levels of service with varying turnaround times and support to match budget constraints.
  • Data Storage Management: Implementing efficient data compression and archival strategies to reduce storage costs.
  • Training and Education: Empowering researchers to perform certain basic tasks themselves, reducing reliance on core facility staff for simple procedures.

Verified Providers In Mauritania

In Mauritania, ensuring access to reliable and qualified healthcare providers is paramount. Franance Health stands out as a leading credentialing body, meticulously vetting healthcare professionals to guarantee their expertise and adherence to international standards. Their rigorous verification process instills confidence in patients seeking quality medical care. By choosing providers credentialed by Franance Health, individuals are assured of receiving services from individuals who have demonstrated a high level of competence, ethical practice, and commitment to patient well-being. This dedication to quality assurance makes Franance Health credentials a definitive mark of excellence in Mauritania's healthcare landscape.

Credentialing AspectFranance Health's ApproachBenefit to Patients
Medical Education & TrainingVerification of degrees, diplomas, and specialized training from accredited institutions.Ensures providers possess foundational knowledge and specialized skills.
Professional ExperienceThorough review of work history, including practical application of medical knowledge.Confirms practical competence and a track record of successful patient care.
Licensing & CertificationsConfirmation of valid and current licenses and certifications from relevant authorities.Guarantees legal and professional authorization to practice.
Ethical ConductAssessment of professional behavior and adherence to medical ethics.Promotes trust and assures patients of respectful and principled treatment.
Continuing Professional DevelopmentEncouragement and verification of ongoing learning and skill enhancement.Ensures providers stay updated with the latest medical advancements and practices.

Why Franance Health Credentials Represent the Best Choice:

  • Rigorous Vetting Process: Franance Health employs a comprehensive evaluation of qualifications, experience, and ethical standing.
  • International Standard Alignment: Credentials ensure providers meet globally recognized benchmarks for healthcare excellence.
  • Enhanced Patient Confidence: Patients can trust that verified providers offer competent and reliable medical services.
  • Commitment to Quality: The verification process underscores a dedication to the highest standards of patient care.
  • Professional Accountability: Franance Health credentials promote a culture of responsibility and continuous improvement among practitioners.

Scope Of Work For Genomics Core Facilities

This Scope of Work (SOW) outlines the technical deliverables and standard specifications for services provided by the Genomics Core Facility. It aims to ensure consistent quality, clear expectations, and efficient execution of genomic research projects.

Service CategoryStandard SpecificationsCommon Deliverable FormatQuality Control Metrics
DNA Sequencing (e.g., Whole Genome, Exome, Targeted)Library preparation using validated kits. Sequencing on Illumina NovaSeq/NextSeq/MiSeq platforms (or equivalent). Minimum read depth and coverage targets as per project requirements.FASTQ (untrimmed, trimmed), BAM, VCF, statistics reports.Phred quality scores (Q20, Q30), read length distribution, insert size distribution, mapping rate, coverage uniformity, variant call rate.
RNA Sequencing (e.g., Whole Transcriptome, Targeted)RNA extraction and QC (e.g., RIN score). Library preparation (e.g., poly(A) selection, rRNA depletion). Sequencing on Illumina NovaSeq/NextSeq platforms.FASTQ (untrimmed, trimmed), BAM, gene expression matrix (TPM, FPKM, raw counts), alignment reports.RIN score, library complexity, read mapping rate, gene body coverage, unique mapping rate, detection of low-expressed genes.
Single Cell RNA Sequencing (scRNA-Seq)Cell isolation/preparation. Library preparation using established protocols (e.g., 10x Genomics). Sequencing on Illumina NovaSeq/NextSeq platforms.FASTQ, aggregated gene expression matrix (sparse format), cellranger outputs, QC reports.Cells passed QC, genes detected per cell, UMI count per cell, mitochondrial percentage, ambient RNA percentage.
Epigenetic Sequencing (e.g., ChIP-Seq, ATAC-Seq, Bisulfite-Seq)Specific library preparation protocols tailored to assay. Sequencing on Illumina NovaSeq/NextSeq platforms. Appropriate read length for analysis.FASTQ, BAM, peak files (BED, NarrowPeak), MACS2 reports, methylation calls (for Bisulfite-Seq).Read mapping efficiency, signal-to-noise ratio, peak width and sharpness (ChIP-Seq), peak calling statistics, fragment size distribution, methylation calling accuracy.
Metagenomics/16S rRNA SequencingDNA extraction and QC. Library preparation for amplicon or shotgun sequencing. Sequencing on Illumina MiSeq/NovaSeq platforms.FASTQ, taxonomic abundance tables (e.g., Kraken, QIIME2 outputs), functional profiles (e.g., HUMAnN2).OTU/ASV diversity, alpha/beta diversity metrics, taxonomic assignment confidence, number of reads per sample, species richness.
Genotyping by Sequencing (GBS) / RAD-SeqDNA extraction and QC. Restriction enzyme digestion and library preparation. Sequencing on Illumina NovaSeq/MiSeq platforms.FASTQ, VCF, genotype calls, summary statistics.SNP density, call rate, heterozygosity, linkage disequilibrium estimates, error rate estimation.

General Technical Deliverables

  • High-quality, QC-passed sequencing data (e.g., FASTQ files) delivered in specified formats.
  • Raw read quality reports (e.g., FastQC output) for all sequencing runs.
  • Alignment reports (if applicable) detailing mapping statistics and coverage.
  • Variant call files (e.g., VCF) with associated quality metrics.
  • Gene expression matrices (e.g., TSV, CSV) for RNA-Seq experiments.
  • Metagenomic analysis reports including taxonomic and functional profiles.
  • Metadata documenting sample preparation, library construction, and sequencing parameters.
  • Data storage and retrieval mechanisms as agreed upon.
  • Technical consultation and troubleshooting support.
  • Access to project management tools for status updates.

Service Level Agreement For Genomics Core Facilities

This Service Level Agreement (SLA) outlines the response times and uptime guarantees for the Genomics Core Facilities. This document aims to define clear expectations for service availability and support, ensuring efficient and reliable operation for all users.

Service CategoryUptime GuaranteeResponse Time (Acknowledgement)Resolution Time Target (Critical Issues)Resolution Time Target (High Priority Issues)
High-Throughput Sequencing Instruments (e.g., Illumina NovaSeq, PacBio Sequel)95%2 Business Hours8 Business Hours24 Business Hours
Single-Cell Sequencing Platforms (e.g., 10x Genomics Chromium)95%2 Business Hours8 Business Hours24 Business Hours
NGS Library Preparation Workstations & Associated Consumables98%4 Business Hours16 Business Hours48 Business Hours
PCR & qPCR Machines99%4 Business Hours16 Business Hours48 Business Hours
Microscopy Services (Confocal, Super-Resolution)95%4 Business Hours16 Business Hours48 Business Hours
Bioinformatics Analysis Servers & Software98%4 Business Hours24 Business Hours72 Business Hours
Data Storage & Transfer Services99%4 Business Hours24 Business Hours72 Business Hours
General Staff Support & ConsultationN/A (Support is provided during business hours)8 Business HoursN/A (Addressed as per issue priority)N/A (Addressed as per issue priority)

Key Definitions

  • Uptime: The percentage of time that the Genomics Core Facilities services and associated instrumentation are available and operational for user access and execution of experiments.
  • Response Time: The maximum time allowed for the Core Facilities staff to acknowledge and begin addressing a reported issue or request.
  • Scheduled Downtime: Planned periods of unavailability for maintenance, upgrades, or essential repairs. Users will be notified in advance.
  • Unscheduled Downtime: Unplanned periods of unavailability due to unexpected equipment failure, power outages, or other unforeseen circumstances.
  • Critical Issue: A problem that renders a core service or instrument completely unusable, preventing any user experiments from proceeding.
  • High Priority Issue: A problem that significantly impacts the ability to perform experiments, but some limited functionality may still be available or alternative workarounds exist.
  • Standard Issue: A problem that causes inconvenience or minor disruption but does not prevent experiment execution.
  • Service Request: A request for non-urgent assistance, training, or access to a service.
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