Molecular Diagnostics Labs in Liberia
Engineering Excellence & Technical Support
Molecular Diagnostics Labs solutions for Clinical & Diagnostic Labs. High-standard technical execution following OEM protocols and local regulatory frameworks.
Advanced PCR & Sequencing Capabilities
Equipped with state-of-the-art Polymerase Chain Reaction (PCR) and next-generation sequencing (NGS) platforms, enabling rapid and precise identification of infectious agents, genetic mutations, and pathogen resistance patterns. This empowers swift diagnosis and targeted treatment strategies for diseases prevalent in Liberia, including malaria, HIV, and emerging infectious threats.
Real-time Disease Surveillance & Outbreak Response
Our molecular diagnostic laboratory facilitates real-time monitoring of disease outbreaks through rapid pathogen identification and characterization. This critical capability allows for timely data analysis, informing public health interventions, resource allocation, and effective containment strategies to protect Liberian communities.
Capacity Building & Local Expertise Development
Dedicated to strengthening Liberia's healthcare infrastructure, our lab invests in comprehensive training programs for local scientists and technicians in advanced molecular diagnostic techniques. This commitment fosters sustainable local expertise, ensuring long-term diagnostic capacity and reducing reliance on external support for critical health challenges.
What Is Molecular Diagnostics Labs In Liberia?
Molecular Diagnostics Laboratories in Liberia represent a critical advancement in healthcare infrastructure, enabling the detection and analysis of diseases at the genetic and protein levels. These facilities employ sophisticated techniques, such as Polymerase Chain Reaction (PCR), nucleic acid sequencing, and immunoassay platforms, to identify specific biological markers associated with various pathogens (viruses, bacteria, parasites), genetic disorders, and cancer. The primary objective is to provide precise, sensitive, and rapid diagnostic information, facilitating early detection, accurate diagnosis, prognosis, and informed treatment decisions. The establishment and operation of these labs are paramount to enhancing public health surveillance, responding to infectious disease outbreaks, and improving the overall quality of medical care within Liberia.
| Who Needs Molecular Diagnostics? | Typical Use Cases |
|---|---|
| Patients with Suspected Infectious Diseases: Individuals presenting with symptoms indicative of viral (e.g., Ebola, HIV, Hepatitis, COVID-19), bacterial, or parasitic infections. | Outbreak Investigation & Surveillance: Rapid identification of causative agents during epidemics to inform public health response strategies and track disease spread. |
| Individuals at Risk of Genetic Disorders: Those with a family history or symptoms suggesting inherited conditions. | Prenatal Screening & Diagnosis: Detecting genetic abnormalities in fetuses. |
| Cancer Patients: For diagnosis, staging, treatment selection (e.g., targeted therapy based on specific mutations), and monitoring of treatment response and recurrence. | Blood Transfusion Services: Screening donated blood for infectious agents to ensure safety. |
| Public Health Agencies: For disease surveillance, monitoring antimicrobial resistance, and evaluating vaccine efficacy. | Research Institutions: For epidemiological studies, pathogen characterization, and development of new diagnostic tools. |
| Healthcare Providers: Requiring precise and timely diagnostic information to guide clinical management and patient care. | Border Control & Travel Medicine: Screening for infectious diseases in travelers to prevent international spread. |
Key Aspects of Molecular Diagnostics in Liberia
- Technology Integration: Utilization of advanced molecular biology instrumentation (e.g., real-time PCR machines, automated nucleic acid extractors, sequencers).
- Specimen Handling: Rigorous protocols for sample collection, preservation, transportation, and processing to maintain analyte integrity.
- Assay Development & Validation: Implementation of validated diagnostic assays tailored to prevalent diseases and local epidemiological context.
- Quality Assurance & Control: Strict adherence to international quality standards (e.g., ISO 15189) and implementation of robust internal quality control measures.
- Data Management & Interpretation: Secure systems for recording, analyzing, and reporting molecular diagnostic results, often integrated with laboratory information systems (LIS).
- Personnel Expertise: Requirement for highly trained personnel including molecular biologists, medical laboratory scientists, technicians, and bioinformaticians.
- Biosafety & Biosecurity: Implementation of stringent biosafety levels (BSL) and biosecurity measures to protect personnel and the environment.
Who Needs Molecular Diagnostics Labs In Liberia?
Molecular diagnostics laboratories are crucial for enhancing healthcare delivery in Liberia. They enable precise identification of diseases, informed treatment decisions, and improved patient outcomes. This technology is particularly vital for combating infectious diseases prevalent in the region, facilitating early detection, and supporting public health initiatives. Beyond direct patient care, these labs are essential for research, training, and the development of a robust national health infrastructure.
| Department/Facility | Key Needs/Applications | Examples of Molecular Tests |
|---|---|---|
| Infectious Disease Departments | Early and accurate diagnosis of viral, bacterial, and parasitic infections; outbreak surveillance; monitoring treatment efficacy. | HIV viral load, Hepatitis B/C testing, Tuberculosis (TB) testing (e.g., GeneXpert), Malaria rapid molecular assays, Ebola virus detection, COVID-19 testing. |
| Oncology Departments | Cancer diagnosis, prognosis, and personalized treatment selection based on genetic mutations. | Cancer biomarker testing (e.g., EGFR mutations in lung cancer, BRAF mutations in melanoma), HPV testing for cervical cancer screening. |
| Maternal and Child Health Units | Diagnosis of congenital infections, newborn screening, monitoring of maternal health. | CMV testing, TORCH infections, Group B Streptococcus screening, genetic disorder screening in newborns. |
| Public Health Laboratories (National Reference Labs) | Disease surveillance, outbreak investigations, quality control of diagnostics, national disease burden estimation. | Wide range of infectious disease testing, antimicrobial resistance profiling, pathogen identification for public health alerts. |
| Research and Academic Institutions | Epidemiological studies, drug discovery and development, understanding disease pathogenesis, training healthcare professionals. | Genotyping, sequencing for pathogen characterization, genetic association studies, novel diagnostic assay development. |
| NGOs and International Health Organizations | Implementing targeted health programs, providing diagnostic services in underserved areas, emergency response. | Similar to public health labs and clinical departments, often focused on specific endemic diseases or during health crises. |
Target Customers and Departments for Molecular Diagnostics Labs in Liberia
- Hospitals and Clinics (Public and Private)
- Research Institutions and Universities
- Public Health Agencies and Government Ministries
- Non-Governmental Organizations (NGOs) involved in healthcare
- International Health Organizations
Molecular Diagnostics Labs Process In Liberia
Molecular diagnostics labs in Liberia, like in many developing nations, operate within a framework that balances essential healthcare needs with resource limitations. The workflow from an inquiry to the execution of a molecular diagnostic test involves several critical stages. This process is often influenced by factors such as the availability of reagents, equipment, trained personnel, and robust infrastructure. The primary goal is to provide accurate and timely diagnostic information to guide patient management and public health interventions.
| Stage | Description | Key Activities | Potential Challenges in Liberia | Importance |
|---|---|---|---|---|
| Inquiry Initiation | The process begins when a healthcare provider identifies a need for molecular diagnostic testing for a patient or a public health concern. | Physician/clinician identifies a suspected condition requiring molecular confirmation (e.g., infectious disease, genetic disorder). | Lack of awareness of available molecular tests; limited access to specialized clinicians; insufficient diagnostic capacity in peripheral areas. | Ensures appropriate tests are requested, preventing unnecessary procedures and optimizing resource use. |
| Sample Collection and Transportation | Appropriate biological samples are collected from the patient and transported to the laboratory under specified conditions. | Collection of blood, swabs, urine, or other bodily fluids. Proper labeling and documentation. Cold chain maintenance for sensitive samples. | Inadequate collection kits; poor transportation infrastructure (road networks, vehicles); lack of reliable cold chain; untrained collection staff; long distances to labs. | Preserves sample integrity and quality, which is crucial for accurate test results. |
| Sample Reception and Accessioning | Upon arrival at the lab, samples are logged, verified, and assigned a unique identifier. | Checking sample integrity and documentation; entering sample details into a Laboratory Information Management System (LIMS) or logbook; assigning unique IDs. | Lack of functional LIMS; manual record-keeping prone to errors; limited lab staff for processing; potential for sample mix-ups. | Ensures proper tracking of samples, accountability, and efficient workflow within the lab. |
| Sample Preparation | The biological sample is processed to isolate the target molecule (e.g., DNA, RNA) or prepare it for the specific molecular assay. | Nucleic acid extraction (manual or automated); centrifugation; filtration; lysis of cells. | Shortage of extraction kits and reagents; unreliable power supply for equipment; limited availability of skilled personnel for complex preparation steps. | Crucial step for obtaining a pure and sufficient quantity of target nucleic acid for amplification and detection. |
| Molecular Assay Execution | The prepared sample is subjected to the specific molecular diagnostic test (e.g., PCR, GeneXpert, sequencing). | Setting up reaction mixtures; running the assay on specialized instruments (e.g., thermocyclers, sequencers); performing amplification and detection steps. | Scarcity of reagents and consumables; equipment malfunction or lack of maintenance; limited access to advanced diagnostic platforms; power outages; limited number of trained technicians. | The core of the diagnostic process, generating the raw data for analysis. |
| Data Analysis and Interpretation | The raw data generated by the assay is analyzed and interpreted by trained personnel. | Reviewing electropherograms, amplification curves, or sequencing data; comparing results to controls and standards; identifying positive/negative results or specific genetic variations. | Limited availability of bioinformaticians or experienced molecular biologists; reliance on manual interpretation which can be time-consuming and error-prone; lack of access to up-to-date reference databases. | Transforms raw data into meaningful diagnostic information. |
| Reporting and Communication | The interpreted results are documented in a formal report and communicated to the requesting healthcare provider. | Generating a laboratory report; ensuring accuracy and completeness of information; timely communication of results (critical for timely treatment). | Delays in report generation due to manual processes; communication challenges with remote healthcare facilities; potential for misinterpretation of reports. | Enables informed clinical decision-making and patient management. |
| Quality Assurance and Control | Ongoing measures are implemented to ensure the accuracy, reliability, and validity of laboratory results. | Running positive and negative controls with each assay batch; participating in external quality assessment (EQA) programs; regular equipment calibration and maintenance; staff training. | Limited access to EQA programs; lack of funding for essential quality control reagents; inconsistent implementation of standard operating procedures (SOPs); difficulty in maintaining equipment. | Essential for maintaining the credibility and usefulness of molecular diagnostic services. |
| Inventory Management and Procurement | Ensuring that necessary reagents, consumables, and equipment are available and procured efficiently. | Tracking stock levels; forecasting needs; managing procurement processes; maintaining proper storage conditions. | Complex procurement procedures; unreliable supply chains; currency fluctuations affecting costs; limited budget for lab supplies; storage challenges (e.g., temperature control). | Underpins the continuous operation of the laboratory by ensuring availability of critical resources. |
Molecular Diagnostics Lab Process in Liberia: Workflow from Inquiry to Execution
- Inquiry Initiation
- Sample Collection and Transportation
- Sample Reception and Accessioning
- Sample Preparation
- Molecular Assay Execution
- Data Analysis and Interpretation
- Reporting and Communication
- Quality Assurance and Control
- Inventory Management and Procurement
Molecular Diagnostics Labs Cost In Liberia
Molecular diagnostics laboratories in Liberia offer a crucial service for disease detection and management. The cost of these services can vary significantly due to a number of factors. These include the specific type of test being performed, the complexity of the diagnostic method, the reagents and consumables required, the laboratory's overhead (staff salaries, equipment maintenance, rent, utilities), and the prevailing economic conditions. The use of imported reagents and specialized equipment can also contribute to higher costs. Furthermore, laboratories in urban centers like Monrovia might have different pricing structures compared to those in more remote areas due to differences in operational expenses and accessibility. While precise, up-to-the-minute pricing is difficult to ascertain without direct consultation with specific labs, it's possible to provide estimated ranges in Liberian Dollars (LRD). It's important to note that these are general estimates and actual prices may differ.
| Test Category (Examples) | Estimated Price Range (LRD) | Notes |
|---|---|---|
| Basic Molecular Tests (e.g., rapid antigen tests for common infections) | 5,000 - 15,000 | Often for viral or bacterial infections. |
| Standard PCR-based Tests (e.g., for common infectious diseases like Malaria, Tuberculosis, HIV) | 10,000 - 30,000 | Price depends on the specific pathogen and assay used. |
| Advanced Molecular Diagnostics (e.g., comprehensive pathogen identification panels, genotyping, some cancer markers) | 25,000 - 75,000+ | These often involve more complex technologies and higher-cost reagents. Prices can be significantly higher for specialized panels. |
| COVID-19 PCR Testing | 15,000 - 35,000 | Prices can fluctuate based on demand and availability of testing kits. |
| Genetic Testing (basic screening) | 40,000 - 100,000+ | Highly variable depending on the scope and technology. May involve external processing for specialized analyses. |
Key Factors Influencing Molecular Diagnostics Lab Costs in Liberia
- Test Type and Complexity
- Reagents and Consumables
- Laboratory Overhead (Staff, Equipment, Utilities, Rent)
- Importation Costs for Supplies
- Geographic Location of the Laboratory
- Economic Conditions and Currency Fluctuations
Affordable Molecular Diagnostics Labs Options
Accessing affordable molecular diagnostics labs is crucial for both individual health management and broader public health initiatives. The cost of these advanced tests can be a significant barrier, but various options and strategies can make them more accessible. Understanding value bundles and implementing smart cost-saving measures are key to navigating the landscape of molecular diagnostics without breaking the bank.
| Strategy/Concept | Explanation | Benefit for Affordability |
|---|---|---|
| Value Bundles | These are packages of related molecular diagnostic tests offered at a reduced price compared to purchasing each test individually. They are often designed for specific conditions or clinical pathways (e.g., a bundle for infectious disease screening, or a genetic panel for a particular cancer risk assessment). | Reduces overall cost by offering a comprehensive set of tests at a discounted rate. Avoids the need for multiple separate orders and potential re-testing if complementary information is required. |
| Preventative Screening Packages | Similar to value bundles, these focus on proactive health monitoring, combining relevant molecular tests to screen for common or hereditary predispositions to certain diseases. Examples include comprehensive cancer panels or cardiac risk assessments. | Early detection through bundled screening can prevent more costly treatments down the line. Offers a cost-effective way to get a broad overview of health risks. |
| Lab Networks & Partnerships | Some healthcare systems or insurance providers have established networks of preferred or partner laboratories. Labs within these networks often offer contracted, lower pricing for molecular diagnostics. | Leverages bulk purchasing power and negotiated rates to offer competitive pricing for services within the network. |
| Comparative Pricing & Online Marketplaces | Utilizing online platforms or actively comparing prices between different CLIA-certified laboratories can reveal significant cost differences for the same molecular tests. | Empowers consumers and healthcare providers to choose the most cost-effective option for necessary testing without compromising quality. |
| Rebate Programs & Coupons | Occasionally, diagnostic labs or manufacturers offer promotional rebates or discount coupons for specific tests or services, especially for Direct-to-Consumer (DTC) offerings. | Provides direct, immediate cost reduction on specific molecular diagnostic tests. |
| Volume Discounts (for Institutions) | For large organizations, hospitals, or public health departments, negotiating significant discounts based on the anticipated volume of tests ordered. | Dramatically lowers the per-test cost, making widespread molecular diagnostics feasible for larger populations. |
| Telehealth Integration | When molecular diagnostics are ordered as part of a telehealth consultation, the overall cost of the healthcare encounter can be reduced, and in some cases, the lab cost might be bundled into the telehealth service fee. | Can streamline the process and potentially integrate lab costs into a broader, more affordable consultation fee. |
Key Considerations for Affordable Molecular Diagnostics
- Understanding Test Necessity: Always discuss with your healthcare provider why a specific molecular diagnostic test is recommended. Not all tests are equally urgent or universally beneficial.
- Insurance Coverage: Thoroughly investigate your health insurance policy. Understand what molecular diagnostic tests are covered, any pre-authorization requirements, and your co-pay/deductible responsibilities.
- Provider Network: Utilize in-network laboratories whenever possible. Out-of-network costs for molecular diagnostics can be substantially higher.
- Direct-to-Consumer (DTC) Options: For certain conditions or wellness screenings, DTC tests can be more affordable, but it's vital to discuss results with a healthcare professional.
- Geographic Location: Lab costs can vary by region. Exploring options in areas with a lower cost of living or higher competition might yield savings.
- Bulk Testing & Public Health Initiatives: For organizations or communities, bulk testing agreements or participation in public health programs can significantly reduce per-test costs.
Verified Providers In Liberia
In Liberia's growing healthcare landscape, the concept of 'Verified Providers' is paramount for ensuring quality and trustworthy medical services. Franance Health stands out as a leading entity that not only understands this critical need but actively addresses it. Their rigorous credentialing process for healthcare professionals and facilities sets a high standard, making them a beacon of reliability for patients seeking the best possible care. This commitment to verification translates into tangible benefits for individuals and the broader health system.
| Credentialing Aspect | Franance Health's Verification | Benefit to Patients |
|---|---|---|
| Educational Background | Verification of degrees, diplomas, and certifications from accredited institutions. | Ensures providers possess the foundational knowledge and training required for effective practice. |
| Licensing and Registration | Confirmation of valid and up-to-date licenses issued by relevant Liberian medical boards. | Guarantees that providers are legally authorized to practice and adhere to regulatory requirements. |
| Professional Experience | Thorough review of work history, including specialty training and previous roles. | Confirms practical experience and suitability for specific medical disciplines. |
| Criminal Background Checks | Mandatory checks to ensure a safe and trustworthy healthcare environment. | Protects patients from potential harm and ensures ethical conduct. |
| Peer Reviews and References | Collection of feedback from colleagues and supervisors where applicable. | Provides insights into a provider's professional reputation and collaborative skills. |
Why Franance Health Credentials Matter:
- Unwavering Commitment to Quality: Franance Health's verification process meticulously checks educational qualifications, licensing, and professional history, ensuring only competent and ethical practitioners are credentialed.
- Patient Safety First: By verifying provider credentials, Franance Health significantly reduces the risk of medical errors and malpractice, prioritizing the well-being of every patient.
- Enhanced Trust and Transparency: The 'Verified Provider' badge instills confidence in patients, offering a clear indication of a healthcare professional's legitimacy and adherence to established standards.
- Facilitating Access to Excellence: Franance Health's network of verified providers connects patients with skilled doctors, nurses, and healthcare facilities, improving access to quality medical services across Liberia.
- Promoting Professional Accountability: The ongoing monitoring and re-verification by Franance Health encourage providers to maintain high ethical and professional standards throughout their careers.
Scope Of Work For Molecular Diagnostics Labs
This Scope of Work (SOW) outlines the technical deliverables and standard specifications required for the establishment and operation of Molecular Diagnostics Laboratories. It covers the essential components from infrastructure to personnel and quality assurance, ensuring the delivery of accurate, reliable, and timely diagnostic services.
| Section | Technical Deliverables | Standard Specifications / Requirements |
|---|---|---|
| Laboratory Infrastructure and Design | Physically secure and appropriately zoned laboratory space | Segregated areas for pre-PCR, PCR, and post-PCR activities; appropriate ventilation (e.g., HEPA filtration); dedicated biosafety cabinets (Class II or III); adequate bench space and storage; cleanroom facilities for specific applications; robust power supply and backup. |
| Equipment and Instrumentation | Nucleic acid extraction systems | Automated or manual systems capable of processing specified sample volumes with high purity and yield; validated for target nucleic acid types (DNA/RNA). |
| Real-time PCR (qPCR) or Digital PCR (dPCR) systems | High throughput capacity; multiple detection channels; high sensitivity and specificity; temperature cycler accuracy and uniformity; integrated software for data analysis and reporting. | |
| Sequencing platforms (e.g., NGS) | Appropriate throughput, read length, and accuracy for intended applications (e.g., WGS, targeted sequencing); robust bioinformatics pipeline integration. | |
| Automated liquid handling systems | High precision and accuracy; adaptable to various labware formats; robotic arms with multiple pipetting channels. | |
| Centrifuges, incubators, vortexers, etc. | Calibrated and maintained according to manufacturer specifications and laboratory protocols. | |
| Reagents and Consumables | Validated assay kits | Commercially available or in-house developed kits with documented performance characteristics (sensitivity, specificity, limit of detection, inclusivity/exclusivity) for target analytes. Certified for IVD use where applicable. |
| Consumables (tubes, plates, pipette tips, etc.) | RNase/DNase-free, PCR-inhibitor-free, certified quality. | |
| Nucleic acid extraction reagents | High purity, consistent performance, validated for target matrices. | |
| Information Technology and Data Management | Laboratory Information Management System (LIMS) | Secure sample tracking; result management; audit trails; integration with instruments; reporting capabilities; compliance with data privacy regulations (e.g., HIPAA, GDPR). |
| Data storage and backup solutions | Secure, redundant storage; regular backups; disaster recovery plan. | |
| Network infrastructure | Reliable and secure network connectivity for instrument integration and data access. | |
| Personnel and Training | Qualified laboratory staff | Trained and certified personnel (e.g., MLT, MSc, PhD) with expertise in molecular biology techniques, instrumentation, and quality control. Defined roles and responsibilities. |
| Training programs | Comprehensive onboarding and ongoing training on SOPs, new assays, instrumentation, and safety protocols. Documented training records. | |
| Quality Assurance and Control | Standard Operating Procedures (SOPs) | Detailed, up-to-date, and approved SOPs for all laboratory processes, including sample handling, testing, data analysis, and instrument maintenance. |
| Quality Control (QC) program | Regular inclusion of positive, negative, and internal controls for all assays. Established QC acceptance criteria and corrective action procedures. | |
| Proficiency Testing (PT) | Participation in external PT programs for all offered tests. Regular internal PT assessments. | |
| Instrument calibration and maintenance logs | Scheduled preventative maintenance and calibration records, traceable and auditable. | |
| Safety and Regulatory Compliance | Biosafety protocols | Adherence to relevant biosafety guidelines (e.g., CDC, WHO, NIH) including BSL levels appropriate for the samples and procedures. Use of appropriate Personal Protective Equipment (PPE). |
| Regulatory approvals and certifications | Compliance with all applicable national and international regulations (e.g., CLIA, ISO 13485, FDA, CE-IVD). Maintenance of necessary licenses and accreditations. | |
| Waste management plan | Safe and compliant disposal of biological and chemical waste. | |
| Test Menu and Assay Development/Validation | Defined test menu | Clear list of molecular diagnostic tests offered, including target analytes, specimen types, and intended use. |
| Assay validation reports | Documented validation studies demonstrating analytical and clinical performance (sensitivity, specificity, PPV, NPV, LoD, etc.) for all assays, whether commercial or in-house developed. | |
| Method comparison studies | If introducing new methods or replacing existing ones, documented comparison studies against established reference methods. |
Key Areas of the Scope of Work
- Laboratory Infrastructure and Design
- Equipment and Instrumentation
- Reagents and Consumables
- Information Technology and Data Management
- Personnel and Training
- Quality Assurance and Control
- Safety and Regulatory Compliance
- Test Menu and Assay Development/Validation
Service Level Agreement For Molecular Diagnostics Labs
This Service Level Agreement (SLA) outlines the performance standards and guarantees for molecular diagnostics laboratory services. It defines specific response times for critical processes and guarantees a minimum level of service uptime.
| Service Component | Response Time Guarantee (Critical Sample) | Response Time Guarantee (Routine Sample) | Uptime Guarantee |
|---|---|---|---|
| Sample Receiving and Pre-analytic Processing | Within 2 hours of arrival | Within 8 business hours of arrival | 99.5% |
| Molecular Assay Initiation (e.g., PCR, sequencing) | Within 4 hours of sample processing | Within 12 business hours of sample processing | 99.5% |
| Result Reporting (Preliminary) | Within 8 hours of assay initiation | Within 24 business hours of assay initiation | 99.0% |
| Result Reporting (Final) | Within 12 hours of assay initiation | Within 48 business hours of assay initiation | 99.0% |
| System Availability (LIS, Instruments) | N/A | N/A | 99.8% |
| Technical Support for Urgent Issues | Within 1 hour of ticket submission | Within 4 business hours of ticket submission | N/A |
Key Definitions
- Response Time: The maximum allowable time from the initiation of a service request (e.g., sample arrival, critical alert) to the commencement of the required action by the laboratory.
- Uptime: The percentage of time that the laboratory's diagnostic systems and services are operational and available for use, excluding scheduled maintenance.
- Critical Sample: A sample requiring immediate analysis due to patient condition or clinical urgency (e.g., sepsis, meningitis, critically ill patients).
- Routine Sample: A sample that does not require immediate analysis and can be processed within standard turnaround times.
- Scheduled Maintenance: Pre-announced periods when laboratory systems may be offline for necessary updates or repairs, which will be communicated in advance.
Frequently Asked Questions
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